Comparison of the European Renal Function Consortium Equation With Chronic Kidney Disease : Epidemiology Collaboration 2021 for Estimating Glomerular Filtration Rate Among Algerian Population With Type 2 Diabetes Mellitus

Zohra Sedoud; Feriel Yasmine Baghdali; Arzour Hind; Ouzriat Massinissa; Deghima Sabrine; Haddoum Farid; Djenouhat Kamel

doi:10.15605/jafes.041.02.6337

Authors

Zohra Sedoud University of Medical Sciences Youcef el Khatib, Algiers, Algeria
Feriel Yasmine Baghdali University of Medical Sciences Youcef el Khatib, Algiers, Algeria https://orcid.org/0009-0009-8045-5649
Arzour Hind University of Medical Sciences Youcef el Khatib, Algiers, Algeria
Ouzriat Massinissa University of Technical Sciences M'hamed Bougara, Boumerdes, Algeria https://orcid.org/0009-0006-7159-9104
Deghima Sabrine University of Medical Sciences Youcef el Khatib, Algiers, Algeria https://orcid.org/0009-0008-2550-5634
Haddoum Farid University of Medical Sciences Youcef el Khatib
Djenouhat Kamel Rouiba Hospital https://orcid.org/0000-0002-1306-7269

DOI:

https://doi.org/10.15605/jafes.041.02.6337

Keywords:

Type 2 diabetes mellitus, estimated glomerular filtration rate, EKFC equation, CKD-EPI equation

Abstract

Introduction. Type 2 diabetes mellitus (T2D) is the leading cause of end stage renal disease. Screening for chronic kidney disease is recommended for early diagnosis and intervention. This requires assessment of renal function by computing for estimated glomerular filtration rate (eGFR) and urine albumin-creatine ratio. Several formulas have been proposed for computation of eGFR. The European Renal Function Consortium (EKFC) equation, obtained by combining the full age spectrum (FAS) and Chronic Kidney Disease – Epidemiology Collaboration 2021 (CKD-EPI) equations, has been proposed as a more universal formula for eGFR. It has the advantage of eliminating correction for ethnicity and covers a wide age range. The aim of this study is to compare the EKFC and CKD-EPI 2021 equations to assess eGFR among Algerian population with T2D.

Methodology. This is an observational, cross-sectional, analytical study. Serum creatinine levels were measured using the Cobas integra 400 Roche diagnostic device. The results were used to estimate GFR using the two formulas: CKD-EPI 2021 and EKFC.

Results. There was a statistically significant difference between the performance of the CKD-EPI 2021 and EKFC equations (p <0.001). However, there was a very good correlation (r = 0.99) even though the EKFC underestimates eGFR compared to CKD-EPI 2021 (bias: -8 ml/min/1.73 m^²).

Conclusions. The main value of the EKFC lies in its ability to provide a detailed stratification in the early stages of chronic kidney disease. Our study also represents the first attempt to establish the q-value in the Algerian population.

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Author Biographies

Zohra Sedoud, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Faculty of Pharmacy, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Central Laboratory Department, Rouiba Hospital, Algiers, Algeria

Feriel Yasmine Baghdali, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Faculty of Medicine, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Nephrology Department, Mustapha Bacha University Hospital, Algiers, Algeria

Arzour Hind, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Faculty of Medicine, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Nephrology Department, Mustapha Bacha University Hospital, Algiers, Algeria

Ouzriat Massinissa, University of Technical Sciences M'hamed Bougara, Boumerdes, Algeria

University of Technical Sciences M'hamed Bougara, Boumerdes, Algeria

Deghima Sabrine, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Faculty of Pharmacy, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Central Laboratory Department, Rouiba Hospital, Algiers, Algeria

Haddoum Farid, University of Medical Sciences Youcef el Khatib

Faculty of Medicine, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

Nephrology Department, Mustapha Bacha University Hospital, Algiers, Algeria

Djenouhat Kamel, Rouiba Hospital

Central Laboratory Department, Rouiba Hospital, Algiers, Algeria

Faculty of Medicine, University of Medical Sciences Youcef el Khatib, Algiers, Algeria

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