Bilateral Genu Valgum in an Adolescent with Primary Hyperparathyroidism

A Case Report and Review of Literature

Authors

DOI:

https://doi.org/10.15605/jafes.035.02.07

Keywords:

primary hyperparathyroidism, adolescent, genu valgum, parathyroid neoplasms

Abstract

Primary hyperparathyroidism in children and adolescents is rare and often symptomatic at presentation. A 15-year-old boy presented with bilateral genu valgum for two years. Biochemical results were consistent with primary hyperparathyroidism. Calcium levels normalized two months after removal of a left inferior parathyroid adenoma.

Downloads

Download data is not yet available.

Author Biographies

Siow Ping Lee, Hospital Sultanah Aminah, Johor

Department of Medicine

Shu Teng Chai, Hospital Sultanah Aminah, Johor

Department of Medicine

Norhaliza Mohd Ali , Hospital Sultanah Aminah, Johor

Department of Medicine

References

Roizen J, Levine MA. Primary hyperparathyroidism in children and adolescents. J Chin Med Assoc. 2012;75(9):425-34. https://www.ncbi.nlm.nih.gov/pubmed/22989537. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710287. https://doi.org/10.1016/j.jcma.2012.06.012.

Alagaratnam S, Kurzawinski TR. Aetiology, diagnosis and surgical treatment of primary hyperparathyroidism in children: New trends. Horm Res Paediatr. 2015. https://www.ncbi.nlm.nih.gov/pubmed/25966652. https://doi.org/10.1159/000381622.

Balch HE, Spiegel EH, Upton AL, Kinsell LW. Hyperparathyroidism: Report of 2 cases with some relatively unusual manifestations. J Clin Endocrinol Metab. 1953;13(6):733-8. https://www.ncbi.nlm.nih.gov/pubmed/13061594. https://doi.org/10.1210/jcem-13-6-733.

Rapaport D, Ziv Y, Rubin M, Huminer D, Dintsman M. Primary hyperparathyroidism in children. J Pediatr Surg. 1986;21(5):395-7. https://www.ncbi.nlm.nih.gov/pubmed/3712190. https://doi.org/10.1016/s0022-3468(86)80505-x.

Roizen J, Levine MA. A meta-analysis comparing the biochemistry of primary hyperparathyroidism in youths to the biochemistry of primary hyperparathyroidism in adults. J Clin Endocrinol Metab.

;99(12):4555-64. https://www.ncbi.nlm.nih.gov/pubmed/25181388. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255125. https://doi.org/10.1210/jc.2014-2268.

McClure RD, Lam CR. End-results in the treatment of hyperparathyroidism. Ann Surg. 1945;121(4):

-66. https://www.ncbi.nlm.nih.gov/pubmed/17858584. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618130. https://doi.org/10.1097/00000658-194504000-00006.

Lloyd HM, Aitken RE, Ferrier TM. Primary hyperparathyroidism resembling rickets of late onset. Brit Med J. 1965;2(5466):853-6. https://www.ncbi.nlm.nih.gov/pubmed/5827800. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1846345. https://doi.org/10.1136/bmj.2.5466.853.

Kauffmann C, Leroy B, Sinnassamy P, Carlioz H, Gruner M, Bensman A. [A rare cause of bone pain in children: Primary hyperparathyroidism caused by adenoma.] Arch Fr Pediatr. 1993;50(9):771-4

[Article in French]. https://www.ncbi.nlm.nih.gov/pubmed/8060206.

Menon PS, Madhavi N, Mukhopadhyaya S, Padhy AK, Bal CS, Sharma LK. Primary hyperparathyroidism in a 14 year old girl presenting with bone deformities. J Paediatr Child Health. 1994;30(5):441-3.https://www.ncbi.nlm.nih.gov/pubmed/7833084. https://doi.org/10.1111/j.1440-1754.1994.tb00698.x.

Harman CR, van Heerden JA, Farley DR, Grant CS, Thompson GB, Curlee K. Sporadic primary hyperparathyroidism in young patients: A separate entity? Arch Surg. 1999;134(6): 651-5. https://www.ncbi.nlm.nih.gov/pubmed/10367876. https://doi.org/10.1001/archsurg.134.6.651.

Walczyk A, Szalecki M, Kowalska A. Primary hyperparathyroidism: A rare endocrinopathy in children. Two case reports. Endokrynol Pol. 2011;62(4):346-50. https://www.ncbi.nlm.nih.gov/pubmed/21879476.

Ratnasingam J, Tan ATB, Vethakkan SR, et al. Primary hyperparathyroidism: A rare cause of genu valgus in adolescence. J Clin Endocrinol Metab. 2013;98(3):869-70. https://www.ncbi.nlm.nih.gov/pubmed/23337722. https://doi.org/10.1210/jc.2012-3839.

Ramkumar S, Kandasamy D, Vijay MK, Tripathi M, Jyotsna VP. Genu valgum and primary hyperparathyroidism in children. Int J Case Rep Images. 2014;5(6):401-7. https://doi:10.5348/ijcri-201455-CS-10041.

Sharma S, Kumar S. Bilateral genu valgum: An unusual presentation of juvenile primary hyperparathyroidism. Oxf Med Case Reports.2016;2016(7):141-3. https://www.ncbi.nlm.nih.gov/pubmed/27471596. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962889. https://doi.org/10.1093/omcr/omw023.

Zil-E-Ali A, Latif A, Rashid A, Malik A, Khan HA. Presentation of parathyroid adenoma with genu valgum and thoracic deformities. J Pak Med Assoc. 2016;66(1):101-3. https://www.ncbi.nlm.nih.gov/pubmed/26712192.

Arambewela MH, Liyanarachchi KD, Somasundaram NP, Pallewatte AS, Punchihewa GL. Case report: Rare skeletal manifestations in a child with primary hyperparathyroidism. BMC Endocr Disord.2017;17(1):45. https://www.ncbi.nlm.nih.gov/pubmed/28732535. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521059. https://doi.org/10.1186/s12902-017-0197-z.

Kamath SP, Shenoy J, Kini KP, Shetty KB, Pai KA. Primary hyperparathyroidism presenting as bilateral genu valgum. Int J Health Allied Sci. 2018;7(2):114-6. https://doi.org/10.4103/ijhas.IJHAS_69_1.

Paruk IM, Pirie FJ, Motala AA. Rickets mimicker: A report of two cases of primary hyperparathyroidism in adolescence. J Endocrinol Metab Diabetes S Afr. 2019; 24(1):23-7. https://doi.org/10.1080/16089677.2018.1546365.

Rao KS, Agarwal P, Reddy J. Parathyroid adenoma presenting as genu valgum in a child: A rare case report. Int J Surg Case Rep. 2019;59:27-30. https://www.ncbi.nlm.nih.gov/pubmed/31102836. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525286.

https://doi.org/10.1016/j.ijscr.2019.03.063.

Yanrismet Y, Tridjaja B. Genu valgum as a rare clinical manifestation in child with primary hyperparathyroidism: A case report. Arch Dis Child. 2019;104(Suppl 3):A276. https://doi.org/10.1136/archdischild-2019-epa.646.

Dutta D, Kumar M, Das RN, et al. Primary hyperparathyroidism masquerading as rickets: Diagnostic challenge and treatment outcomes. J Clin Res Pediatr Endocrinol. 2013;5(4):266-9. https://www.ncbi.nlm.nih.gov/pubmed/24379038. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890227. https://doi.org/10.4274/Jcrpe.1060.

Khan KA, Qureshi SU. Primary hyperparathyroidism masquerading as rickets. J Coll Physicians Surg Pak. 2019;29(9):891-4. https://www.ncbi.nlm.nih.gov/pubmed/31455490. https://doi.org/10.29271/jcpsp.2019.09.891.

Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M, Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics.2008;122(2):398-417. https://www.ncbi.nlm.nih.gov/pubmed/18676559. https://doi.org/10.1542/peds.2007-1894.

Published

2020-11-29

How to Cite

Lee, S. P., Chai, S. T. ., Loh, L. T. ., & Mohd Ali , N. (2020). Bilateral Genu Valgum in an Adolescent with Primary Hyperparathyroidism: A Case Report and Review of Literature. Journal of the ASEAN Federation of Endocrine Societies, 35(2), 220–223. https://doi.org/10.15605/jafes.035.02.07

Issue

Section

Case Reports

Most read articles by the same author(s)