Prevalence of Undiagnosed Autoimmune Thyroid Disease and Thyroid Dysfunction in Filipino Patients with Autoimmune Rheumatic Disorders

Authors

  • Cristina V. Jaring Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital
  • Elizabeth Paz-Pacheco Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital
  • Cecilia A. Jimeno Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital
  • Ester Z. Gonzales-Penserga Section of Rheumatology, Department of Medicine, Philippine General Hospital
  • Celestelyn G. Barredo Section of Rheumatology, Department of Medicine, Philippine General Hospital

Abstract

Objectives. (1) To determine the prevalence of autoimmune thyroid disease among patients with autoimmune rheumatic disorders seen at the Philippine General Hospital. (2) To determine clinical features that are associated with the occurrence of autoimmune thyroid disease in these patients.

 

Methodology. This is a cross sectional analytical study that included 155 adult Filipinos diagnosed with an autoimmune rheumatic disorder. Clinical characteristics were recorded. Serum thyrotropin, thyroxine, triiodothyronine, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody and urinary iodide excretion were determined. The prevalence of autoimmune thyroid disease was computed. Associations between clinical factors and autoimmune thyroid disease were determined.

 

Results. Overall 21.94% of the population had autoimmune thyroid disease. There was significant association between duration of the autoimmune rheumatic disorder and autoimmune thyroid disease (p-= 0.018). No significant association was noted with the other clinical factors although there was an almost significant association observed for the presence of goiter (p=0.054).

 

Conclusion. Autoimmune thyroid disease commonly occurs in patients with autoimmune rheumatic disorders. As such, it is important to consider screening these patients for the coexistence of thyroid disease to help prevent the complications associated with thyroid dysfunction and avoid adding up to the morbidity of the existing autoimmune rheumatic disorder.

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References

Boelaert K, Newby P, Simmonds M, et al. Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. American Journal of Medicine. 2010; 123:183.e1-183.e9.

Weetman P. Non-thyroid autoantibodies in autoimmune thyroid disease. Best Practice & Research Clinical Endocrinology & Metabolism. 2005; 19(1):17-32.

Biro E, Szekanecz Z, Czirjak L, et al. Association of systemic and thyroid autoimmune diseases. Clinical Rheumatology. 2006; 25(2):240-245.

Lazurova I, Benhatchi K, Rovensky J, et al. Autoimmune Thyroid Disease and Autoimmune Rheumatic Disorders: A Two-sided Analysis. Annals of the New York Academy of Sciences. 2009; 1173:211-216.

Porkodi R, Ramesh S, Mahesh A, et al. Thyroid dysfunction in systemic lupus erythematosus and rheumatoid arthritis. J Indian Rheumatol Assoc. 2004; 12:88-90.

Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis. 2002; 61:70-72.

Antonelli A, Fallahi P, Mosca M, et al. Prevalence of thyroid dysfunctions in systemic lupus erythematosus. Metabolism Clinical and Experimental. 2010; 59:896-900.

Appenzeller S, Pallone A, Natalin R, et al. Prevalence of thyroid dysfunction in systemic lupus erythematosus. Journal of Clinical Rheumatology. 2009; 15(3):117-119.

Atzeni F, Doria A, Ghirardello A, et al. Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: Prevalence and clinical value. Autoimmunity. 2008; 41(1):111-115.

Boey ML, Fong PH, Lee JSC, et al. Autoimmune thyroid disorders in SLE in Singapore. Lupus. 1993; 2:51-54.

Park DJ, Cho CS, Lee SH, et al. Thyroid disorders in Korean patients with systemic lupus erythematosus. Scandinavian Journal of Rheumatology. 1995; 24(1):13-17.

Tsai RT, Chang TC, Wang CR, et al. Thyroid disorders in Chinese patients with systemic lupus erythematosus. Rheumatology International. 1993; 13(1):9-13.

Soldevilla HF, Navarra SV. Thyroid disorders in Filipino patients with systemic lupus erythematosus. University of Santo Tomas Hospital, Manila. (Unpublished).

Goncalves F, Taciana C, Ranza R, et al. Autoimmune thyroiditis and rheumatoid arthritis: Is there really an association? The Endocrinologist. 2009; 19(1):31-34.

Ladenson P, Singer P, Ain K, et al. American Thyroid Association Guidelines for Detection of Thyroid Dysfunction. Arch Intern Med. 2000; 160:1573-1575.

Fauci A, Braunwald E, Kasper D, et al, eds. Harrison’s Principles of Internal Medicine, 17th edition. USA: McGraw-Hill, 2008.

1980 Criteria for the Classification of Systemic Sclerosis. http://www.rheumatology.org/practice/clinical/classification/systsclr.asp. Accessed August 2010.

Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorders in the community: A twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995; 43:55-68.

Published

2014-05-21

How to Cite

Jaring, C. V., Paz-Pacheco, E., Jimeno, C. A., Gonzales-Penserga, E. Z., & Barredo, C. G. (2014). Prevalence of Undiagnosed Autoimmune Thyroid Disease and Thyroid Dysfunction in Filipino Patients with Autoimmune Rheumatic Disorders. Journal of the ASEAN Federation of Endocrine Societies, 27(1), 67. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/15

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