Collision of Two Tumors

A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma




collision tumor, pituitary adenoma, pituitary metastasis


Acollision tumor involving metastasis to a pituitary adenoma is rare. We describe a case of a 68-year-old Bidayuh woman with underlying treatment-responsive lung adenocarcinoma, who presented with mass effect, panhypopituitarism and polyuria. Her initial imaging study reported pituitary macroadenoma, and she was treated with hormone replacement therapy. She then underwent transsphenoidal tumor debulking surgery with subsequent histopathological findings of a collision tumor of an adenocarcinoma with metastasis to a non-functioning pituitary adenoma.


Download data is not yet available.


Sogani J, Yang W, Lavi E, Zimmerman RD, Gupta A. Sellar collision tumor involving metastatic lung cancer and pituitary adenoma: Radiologic-pathologic correlation and review of the literature. Clin Imaging. 2014;38(3):318-21.

Lamorie-Foote K, Rangwala SD, Kammen A, et al. Melanoma metastasis to a nonfunctioning pituitary macroadenoma: Illustrative case. J Neurosurg Case Lessons. 2021;1(23):CASE2167.

Helton M, Abu-Rmaileh M, Thomas K, Gokden M, Kanaan A, Rodriguez A. Pituitary metastatic composite tumors: A case report with next-generation sequencing and review of the literature. Case Rep Oncol Med. 2020;2020:5073236.

Hoellig A, Niehusmann P, Flacke S, Kristof RA. Metastasis to pituitary adenoma: Case report and review of the literature. Cent Eur Neurosurg. 2009;70(3):149-53.

Chhiber SS, Bhat AR, Khan SH, et al. Apoplexy in sellar metastasis: A case report and review of literature. Turk Neurosurg. 2011;21(2):230-4.

Shimon I. Metastatic spread to the pituitary. Neuroendocrinology. 2020;110(9-10):805-8.

Turner HE, Harris AL, Melmed S, Wass JAH. Angiogenesis in endocrine tumors. Endocr Rev. 2003;24(5):600-32.

Gupta K, Sahni S, Saggar K, Vashisht G. Evaluation of clinical and magnetic resonance imaging profile of pituitary macroadenoma: A prospective study. J Nat Sci Biol Med. 2018;9(1):34-8.

Wang S, Lin K, Xiao D, Wei L, Zhao L. The relationship between posterior pituitary bright spot on magnetic resonance imaging (MRI) and postoperative diabetes insipidus for pituitary adenoma patients. Med Sci Monit. 2018;24:6579-86.

Komninos J, Vlassopoulou V, Protopapa D, et al. Tumors metastatic to the pituitary gland: Case report and literature review. J Clin Endocrinol Metab. 2004;89(2):574-80.

Ng S, Fomekong F, Delabar V, et al. Current status and treatment modalities in metastases to the pituitary: A systematic review. J Neurooncol. 2020;146(2):219-27.

Kim YH, Lee BJ, Lee KJ, Cho JH. A case of pituitary metastasis from breast cancer that presented as left visual disturbance. J Korean Neurosurg Soc. 2012;51(2):94-7. PMID: 22500201.



How to Cite

Borhan, M. K., Tan, F. H. S., & Awang Basry, N. S. (2022). Collision of Two Tumors: A Case Report of a Lung Adenocarcinoma With Metastasis to a Pituitary Adenoma. Journal of the ASEAN Federation of Endocrine Societies, 37(2), 89–94.



Case Reports

Similar Articles

You may also start an advanced similarity search for this article.