Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly

Real-World Evidence from the Malaysian Acromegaly Registry



acromegaly, malaysian registry, healthcare resource utilization, treatment outcomes


Objective. This study is intended to report the demographic features of patients with acromegaly the disease burden, treatment patterns as well as the corresponding treatment outcome in Malaysia.

Methodology. Data from the Malaysian Acromegaly registry was retrospectively collected and included patients diagnosed with acromegaly from 1970 onwards. Data collected included patient demographics, clinical sign and symptoms as well as clinical manifestations of acromegaly, biochemical results and imaging information. Information regarding treatment modality and therapeutic outcome of different modalities of treatment were also collected.

Results. Data from the registry was collected from 2013-2016 and included 140 patients with acromegaly from 12 participating hospitals. Median disease duration was 5.5 years (range 1.0 – 41.0 years). Most patients had macroadenoma (67%) while a minority were diagnosed with microadenoma (15%). Hypertension (49.3%), diabetes (37.1%) and hypopituitarism (27.9%) were the most common co-morbidities for patients with acromegaly. Majority of patients had first line surgical intervention (65.9%) while 20.7% had first line medical treatment, mainly with dopamine agonist (18.5%). Most patients had inadequate disease control after first line treatment regardless of treatment modality (79.4%).

Conclusion. This registry study provides the epidemiology data of patients with acromegaly in Malaysia and serves as an initial step for further population-based studies.


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Author Biographies

Mohamed Badrulnizam Long Bidin, Hospital Kuala Lumpur, Malaysia

Consultant Endocrinologist

Florence Hui Sieng Tan, Hospital Umum Sarawak, Malayisa

Consultant Endocrinologist

Nor Azizah Aziz, Hospital Pulsu Pinang, Malaysia

Consultant Endocrinologist

Norhaliza Mohd Ali, Hospital Sultanah Aminah Johor Bahru, Malaysia

Consultant Endocrinologist

Nor Azmi Kamaruddin, Hospital Canselor Universiti Malaya, Malaysia

Consultant Endocrinologist

Shireene Vethakkan, Pusat Perubatan Universiti Malaya, Malaysia

Consultant Endocrinologist

Abdul Mueed Khan, Novartis Corporation (M) Sdn Bhd, Malaysia

Medical Manager

Balraj Sethi, Novartis Corporation (M) Sdn Bhd, Malaysia

Medical Director

Zanariah Hussein, Hospital Putrajaya, Malaysia

Consultant Endocrinologist


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How to Cite

Long Bidin, M. B., Tan, F. H. S., Aziz, N. A., Mohd Ali, N. ., Kamaruddin, N. A., Vethakkan, S., Khan, A. M., Sethi, B., & Hussein, Z. (2022). Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly: Real-World Evidence from the Malaysian Acromegaly Registry. Journal of the ASEAN Federation of Endocrine Societies. Retrieved from



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