Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly

Real-World Evidence from the Malaysian Acromegaly Registry




acromegaly, malaysian registry, healthcare resource utilization, treatment outcomes


Objective. This study aims to report the demographic features of patients with acromegaly the disease burden, and the corresponding treatment patterns and outcomes in Malaysia.

Methodology. This is a retrospective study that included patients from the Malaysian Acromegaly registry who were diagnosed with acromegaly from 1970 onwards.  Data collected included patient demographics, clinical manifestations of acromegaly, biochemical results and imaging findings. Information regarding treatment modalities and their outcomes was also obtained.

Results. Registry data was collected from 2013 to 2016 and included 140 patients with acromegaly from 12 participating hospitals. Median disease duration was 5.5 years (range 1.0 – 41.0 years). Most patients had macroadenoma (67%), while 15% were diagnosed with microadenoma. Hypertension (49.3%), diabetes (37.1%) and hypopituitarism (27.9%) were the most common co-morbidities for patients with acromegaly. Majority of patients had surgical intervention as primary treatment (65.9%) while 20.7% were treated medically, mainly with dopamine agonists (18.5%). Most patients had inadequate disease control after first-line treatment regardless of treatment modality (79.4%).

Conclusion. This registry study provides epidemiological data on patients with acromegaly in Malaysia and serves as an initial step for further population-based studies.


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Author Biographies

Mohamed Badrulnizam Long Bidin, Hospital Kuala Lumpur, Jalan Pahang, Malaysia

Consultant Endocrinologist

Abdul Mueed Khan, Novartis Corporation (M) Sdn Bhd, Petaling Jaya, Selangor, Malaysia

Medical Manager

Florence Hui Sieng Tan, Hospital Umum Sarawak, Sarawak, Malaysia

Consultant Endocrinologist

Nor Azizah Aziz, Hospital Pulau Pinang, Pulau Pinang, Malaysia

Consultant Endocrinologist

Norhaliza Mohd Ali, Hospital Sultanah Aminah Johor Bahru, Johor Bahru, Malaysia

Consultant Endocrinologist

Nor Azmi Kamaruddin, Hospital Canselor Universiti Malaya, Kuala Lumpur, Malaysia

Consultant Endocrinologist

Shireene Vethakkan, Pusat Perubatan Universiti Malaya, Kuala Lumpur, Malaysia

Consultant Endocrinologist

Balraj Sethi, Novartis Corporation (M) Sdn Bhd, Petaling Jaya, Selangor, Malaysia

Medical Director

Zanariah Hussein, Hospital Putrajaya, Putrajaya, Malaysia

Consultant Endocrinologist


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How to Cite

Long Bidin, M. B., Khan, A. M., Tan, F. H. S., Aziz, N. A., Mohd Ali, N. ., Kamaruddin, N. A., Vethakkan, S., Sethi, B., & Hussein, Z. (2023). Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly: Real-World Evidence from the Malaysian Acromegaly Registry. Journal of the ASEAN Federation of Endocrine Societies, 38(1), 75–80.



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