EVALUATION OF CANDIDATE GENETIC VARIATIONS AS PHARMACOGENETIC MARKERS FOR METFORMIN AMONG FILIPINOS

Authors

  • Elizabeth Paz-Pacheco Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines – Philippine General Hospital Manila
  • Eva Maria Cutiongco-de la Paz Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila
  • Jose Nevado Jr. Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila
  • Gabriel Jasul Jr. Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of the Philippines – Philippine General Hospital Manila
  • May Uyking-Naranjo Southern Philippines Medical Center
  • Ma. Luz Vicenta Guanzon Corazon Locsin Montelibano Memorial Regional Hospital, Bacolod, Negros Occidental, Philippines
  • Karell Jo Angelique Calpito Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila
  • Elizabeth Laurize Alejandro Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila
  • Vincent Sean Ribaya Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila
  • Julius Patrick Ferrer Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Keywords:

pharmacogenetics, diabetes mellitus, type 2, metformin

Abstract

INTRODUCTION
This study aims to determine the genetic polymorphisms associated with drug response to metformin in type 2 diabetes mellitus (T2DM).

METHODOLOGY
Unmatched cases and controls were used to test the association of genetic polymorphisms in candidate genes to test drug response to metformin. Two hundred fifteen patients with type 2 diabetes who were diagnosed within the past 3 years, without recent T2DM treatment were enrolled simultaneously from three (3) hospitals from Luzon, Visayas and Mindanao and various communities around its area. The participants were started on metformin as monotherapy for 3 months. Glycosylated hemoglobin (HbA1c) was measured at baseline and after 3 months of treatment. Genotyping was done using customized Illumina Infinium microarray chips. Candidate variants were then correlated with response using logistic regression analysis.

PRELIMINARY RESULTS and DISCUSSION
There are three (3) candidate genetic variants significantly associated to metformin response in this study. The two most significant single nucleotide polymorphisms (SNPs) are variants of the gene FK506-binding protein 5 gene (FKBP5) (AA > AC > CC: OR 3.44, 95% CI 1.67, 7.76; p-value 0.0004 and CC > CT > TT: OR 3.45, 95% CI 1.64, 8.06; p-value 0.0006, respectively).

CONCLUSION
The study revealed SNPs that were not previously associated with metformin response. Genetic variation exists among Filipinos and these influence treatment responses to oral hypoglycemic agents. This study on the genetics of Filipinos with diabetes will potentially benefit the population with use of appropriate medications.

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Author Biographies

Eva Maria Cutiongco-de la Paz, Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Philippine Genome Center, University of the Philippines,
Diliman, Quezon City

Karell Jo Angelique Calpito, Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Philippine Genome Center, University of the Philippines,
Diliman, Quezon City

Elizabeth Laurize Alejandro, Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Philippine Genome Center, University of the Philippines,
Diliman, Quezon City

Vincent Sean Ribaya, Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Philippine Genome Center, University of the Philippines,
Diliman, Quezon City

Julius Patrick Ferrer, Institute of Human Genetics, National Institutes of Health, University of the Philippines, Manila

Philippine Genome Center, University of the Philippines,
Diliman, Quezon City

References

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Published

2022-06-01

How to Cite

Paz-Pacheco, E. ., Cutiongco-de la Paz, E. M., Nevado Jr., J. ., Jasul Jr., G., Uyking-Naranjo, M., Guanzon, M. L. V., Calpito, K. J. A., Alejandro, E. L., Ribaya, V. S., & Ferrer, J. P. (2022). EVALUATION OF CANDIDATE GENETIC VARIATIONS AS PHARMACOGENETIC MARKERS FOR METFORMIN AMONG FILIPINOS. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 29. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1959

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Section

Abstracts of Original Articles | Prediabetes, Diabetes Mellitus, Hypoglycemia

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