A Case of Toxic Multinodular Goiter with Anaplastic Carcinoma

Authors

  • Perie Adorable-Wagan Section of Endocrinology and Metabolism, The Medical City Hospital, Pasig City, Philippines
  • Audrey Martinez Department of Laboratories, The Medical City Hospital, Pasig City, Philippines
  • Ma.Theresa Chua-Agcaoili Section of Endocrinology and Metabolism, The Medical City Hospital, Pasig City, Philippines
  • Elizabeth Ann Samaniego Alcazaren Department of Laboratories, The Medical City Hospital, Pasig City, Philippines

Abstract

This report concerns a 71-year-old female with long standing untreated toxic multinodular  goiter (TMG) coexisting with anaplastic thyroid carcinoma who presented with progressive shortness of breath and easy fatigability. Thyroid function tests showed suppressed TSH and elevated FT4 and FT3. Anti-thyroid hormone drugs were started. Thyrotropin receptor antibody was negative.  A thyroid scan revealed both hot and cold nodules and fine needle aspiration biopsy (FNAB) of the thyroid gland  showed colloid nodule. Chest CT scan imaging revealed an enlarged thyroid gland with the right lobe  compressing the trachea. Patient underwent total thyroidectomy, final histopathology showed  Anaplastic thyroid carcinoma. Our case is interesting from a pathophysiologic perspective,since it suggests that TMG can potentially transform into an aggressive form of thyroid carcinoma. High index of suspicion in patients with TMG   with other  risk factors for malignancy requires careful evaluation to detect cancer.

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Published

2014-05-22

How to Cite

Adorable-Wagan, P., Martinez, A., Chua-Agcaoili, M., & Samaniego Alcazaren, E. A. (2014). A Case of Toxic Multinodular Goiter with Anaplastic Carcinoma. Journal of the ASEAN Federation of Endocrine Societies, 27(1), 109. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/24

Issue

Vol. 27 No. 1 (2012): May Issue

Section

Case Reports

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