Characteristics and Prevalence of Metabolic Syndrome among Adult Filipinos with Hypothyroidism: A Cross-sectional Study

Harold Henrison Chiu; Emilio Villanueva III; Ramon Larrazabal Jr.; Anna Elvira Arcellana; Cecilia Jimeno

doi:10.15605/jafes.039.01.13

Authors

Harold Henrison Chiu Philippine General Hospital https://orcid.org/0000-0002-2021-7843
Emilio Villanueva III University of the Philippines Manila https://orcid.org/0000-0001-8543-9239
Ramon Larrazabal Jr. Philippine General Hospital https://orcid.org/0000-0003-4538-416X
Anna Elvira Arcellana Philippine General Hospital https://orcid.org/0000-0003-2964-7214
Cecilia Jimeno Philippine General Hospital https://orcid.org/0000-0002-7658-0123

DOI:

https://doi.org/10.15605/jafes.039.01.13

Keywords:

dyslipidemia, hypothyroidism, metabolic syndrome, prevalence

Abstract

Objectives. We determined the clinical characteristics and prevalence of metabolic syndrome among adult Filipinos with overt hypothyroidism.

Methodology. This is a cross-sectional study of 151 adults. Patients were recruited by sequential enrollment. Anthropometric and blood pressure measurements were performed followed by blood extraction for metabolic parameters and thyroid function tests. Clinical and laboratory characteristics were compared between patients with and without metabolic syndrome.

Results. The prevalence of metabolic syndrome is 40.4% (95%CI: 32.5%, 48.7%). Patients with metabolic syndrome have a waist circumference of 88.4 ± 7.7 cm in females and 93.3 ± 9.0 cm in males. The median fasting blood glucose was 111.4 (52.2) mg/dL, median systolic blood pressure of 120 (30) mm Hg and diastolic blood pressure of 80 (20) mmHg, median serum triglycerides of 174.3 (114.2) mg/dL, median HDL-C of 42.3 (19.2) mg/dL and a proportion of patients with diabetes (23.0%) and hypertension (44.3%), respectively. The presence of increased waist circumference is the most prevalent component seen among hypothyroid patients. There were no differences in terms of age, sex, etiology of hypothyroidism and anti-TPO levels in those with and without metabolic syndrome.

Conclusion. The prevalence of metabolic syndrome in adult Filipinos with hypothyroidism is high. Emphasis must be placed on early screening using waist circumference and metabolic parameters among hypothyroid patients who are at high risk of developing metabolic syndrome.

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Author Biographies

Harold Henrison Chiu, Philippine General Hospital

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila

Emilio Villanueva III, University of the Philippines Manila

Department of Pathology, College of Medicine, University of the Philippines Manila

Ramon Larrazabal Jr., Philippine General Hospital

Department of Medicine, Philippine General Hospital, University of the Philippines Manila

Anna Elvira Arcellana, Philippine General Hospital

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila

Cecilia Jimeno, Philippine General Hospital

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila

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