Microvascular and Macrovascular Complications in Young-onset Type 2 Diabetes in a Tertiary Health Institution in Malaysia in Comparison with Type 1 Diabetes Patients

Authors

  • Kim Piow Lim Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Siew Hui Foo Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Kean Yew Liew Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Kavitha Arumugam Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Nurafna Mohd Jaafar Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Yung Zhuang Choo Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia
  • Yen Shen Wong Endocrine Unit, Department of Medicine, Selayang Hospital, Selangor, Malaysia

Keywords:

young- onset type 2 diabetes, diabetic complications, type 1 diabetes

Abstract

*Visual Abstracts prepared by Dr. Carmen Carina Cabrera

Objectives: To compare the rate of diabetes complications in young-onset type 2 diabetes (T2DM) with type 1 diabetes (T1DM) patients and to examine the relationship between diabetes complications with clinical and metabolic parameters.

Methodology: This is a retrospective,comparative study based on electronic medical records review. Young-onset T2DM patients defined as those with disease onset before the age of 40 and T1DM patients were included. Data was collected on demographic and clinical parameters, cardiovascular risks factors, macrovascular and microvascular complications.

Results: There were 194 young-onset T2DM and 45 T1DM subjects. Despite similar glycemic profile, more subjects in the T2DM group hadunfavourable cardiovascular risk factors and developedmacro- or microvascular complications than the T1DM group (22 vs. 0%, p< 0.001for macrovascular, 68 vs. 40%, p< 0.001 for microvascular). Afteradjustment ofthe confounders, young-onset T2DM remained an independent predictor for both macrovascular and microvascular complications in the overall cohort (HR= 2.635, p= 0.022).

Conclusion:Young-onset T2DM appeared to be a more aggressive disease compared to T1DM. An aggressive approach should be adopted in treating young-onset T2DM to optimise the cardiovascular risk factors and glycemic control to prevent premature mortality and morbidity.

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Published

2016-09-02

How to Cite

Lim, K. P., Foo, S. H., Liew, K. Y., Arumugam, K., Mohd Jaafar, N., Choo, Y. Z., & Wong, Y. S. (2016). Microvascular and Macrovascular Complications in Young-onset Type 2 Diabetes in a Tertiary Health Institution in Malaysia in Comparison with Type 1 Diabetes Patients. Journal of the ASEAN Federation of Endocrine Societies, 31(2), 125. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/305

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Original Articles