Common Variable Immunodeficiency and Type 1 Diabetes Mellitus in a 19-year-old Filipino Male with Alopecia Universalis

Authors

  • Maria Princess Landicho Section of Endocrinology, Diabetes and Metabolism, Makati Medical Center, Philippines
  • Maria Jocelyn Isidro Section of Endocrinology, Diabetes and Metabolism, Makati Medical Center, Philippines
  • Marysia Stella Recto Section of Allergy and Immunology, University of the Philippines-Philippine General Hospital and Makati Medical Center, Philippines

Abstract

A 19-year-old Filipino male presents with recurrent respiratory tract symptoms every 4 to 5 months since childhood and sudden onset of diabetes type 1 with ketoacidosis. He had patchy hair loss which started at 7 years old, and was diagnosed with  alopecia universalis. Thyroid antibodies and 21-hydroxylase antibody were normal. Common Variable Immunodeficiency with Polyglandular Autoimmune Syndrome IV was considered. The patient is on monthly intravenous immunoglobulin therapy and basal bolus insulin regimen.

Downloads

Download data is not yet available.

References

Steihm ER, Ochs HD et al eds. Immuologicdisordersin infants and children, 5th edition Philadelphia PA; Elsevier Saunders 2004.

Agarwal S, Cunningham-Rundles C. Autoimmunity in common variable immunodeficiency, Curr Allergy Asthma Rep. September 2009 ; 9(5):347–352.

Cutiongco-Dela Paz, E. 66th Inter-hospital Grand rounds of the Philippine Society of Endocrinology and Metabolism, Makati Medical Center , May 2011.

Vorechovsky I, Zetterquist H, Paganelli R et al. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin. Immunol. Immunopathol. 1995;77:185-192.

Chapel H and Cuninnham-Rundles, C. Br J Haematol 2009;145(6):709-727.

Petukhova L, Duvic M, Hordinsky M, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. Jul 1 2010;466(7302):113-117.

American Diabetes Association: Standards of Medical Care in Diabetes—2011, Diabetes Care. January 2011; 34(1): S11-S61.

Jameson JL, De Groot LJ. Endocrinology, Adult and Pediatric 6th ed. 2010.

Gardner DG, Shoback D. Greenspan’s Basic and Clinical Endocrinology, 9th ed. McGraw Hill Companies, Inc. 2011:588.

Bergbreiter A, Salzer U. Common variable immunodeficiency: A multifaceted and puzzling disorder. Expert Rev ClinImmunol. 2009;5(2):167-180.

Van den Driessche A, Eenkhoorn V, Van Gaal L, De Block C. Type 1 diabetes and autoimmune polyglandular syndrome: A clinical review. The Netherlands Journal of Medicine, December 2009; 67 (11) 376-387.

Kahaly, GJ. Polyglandular autoimmune syndromes. European Journal of Endocrinology.2009;161: 11–20.

Neufeld M, Maclaren N, Blizzard R. Polyglandular autoimmune diseases.Pediatr Ann. 1980;9(4):154-62.

Bayry J et al. J Autoimmun. Feb 2012; 36 (1):9-15.

Published

2014-05-24

How to Cite

Landicho, M. P., Jocelyn Isidro, M., & Recto, M. S. (2014). Common Variable Immunodeficiency and Type 1 Diabetes Mellitus in a 19-year-old Filipino Male with Alopecia Universalis. Journal of the ASEAN Federation of Endocrine Societies, 28(1), 83. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/57

Issue

Section

Interhospital Grand Rounds