Common Variable Immunodeficiency and Type 1 Diabetes Mellitus in a 19-year-old Filipino Male with Alopecia Universalis
Abstract
A 19-year-old Filipino male presents with recurrent respiratory tract symptoms every 4 to 5 months since childhood and sudden onset of diabetes type 1 with ketoacidosis. He had patchy hair loss which started at 7 years old, and was diagnosed with alopecia universalis. Thyroid antibodies and 21-hydroxylase antibody were normal. Common Variable Immunodeficiency with Polyglandular Autoimmune Syndrome IV was considered. The patient is on monthly intravenous immunoglobulin therapy and basal bolus insulin regimen.Downloads
References
Steihm ER, Ochs HD et al eds. Immuologicdisordersin infants and children, 5th edition Philadelphia PA; Elsevier Saunders 2004.
Agarwal S, Cunningham-Rundles C. Autoimmunity in common variable immunodeficiency, Curr Allergy Asthma Rep. September 2009 ; 9(5):347–352.
Cutiongco-Dela Paz, E. 66th Inter-hospital Grand rounds of the Philippine Society of Endocrinology and Metabolism, Makati Medical Center , May 2011.
Vorechovsky I, Zetterquist H, Paganelli R et al. Family and linkage study of selective IgA deficiency and common variable immunodeficiency. Clin. Immunol. Immunopathol. 1995;77:185-192.
Chapel H and Cuninnham-Rundles, C. Br J Haematol 2009;145(6):709-727.
Petukhova L, Duvic M, Hordinsky M, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. Jul 1 2010;466(7302):113-117.
American Diabetes Association: Standards of Medical Care in Diabetes—2011, Diabetes Care. January 2011; 34(1): S11-S61.
Jameson JL, De Groot LJ. Endocrinology, Adult and Pediatric 6th ed. 2010.
Gardner DG, Shoback D. Greenspan’s Basic and Clinical Endocrinology, 9th ed. McGraw Hill Companies, Inc. 2011:588.
Bergbreiter A, Salzer U. Common variable immunodeficiency: A multifaceted and puzzling disorder. Expert Rev ClinImmunol. 2009;5(2):167-180.
Van den Driessche A, Eenkhoorn V, Van Gaal L, De Block C. Type 1 diabetes and autoimmune polyglandular syndrome: A clinical review. The Netherlands Journal of Medicine, December 2009; 67 (11) 376-387.
Kahaly, GJ. Polyglandular autoimmune syndromes. European Journal of Endocrinology.2009;161: 11–20.
Neufeld M, Maclaren N, Blizzard R. Polyglandular autoimmune diseases.Pediatr Ann. 1980;9(4):154-62.
Bayry J et al. J Autoimmun. Feb 2012; 36 (1):9-15.
Published
How to Cite
Issue
Section
License
Journal of the ASEAN Federation of Endocrine Societies is licensed under a Creative Commons Attribution-NonCommercial 4.0 International. (full license at this link: http://creativecommons.org/licenses/by-nc/3.0/legalcode).
To obtain permission to translate/reproduce or download articles or use images FOR COMMERCIAL REUSE/BUSINESS PURPOSES from the Journal of the ASEAN Federation of Endocrine Societies, kindly fill in the Permission Request for Use of Copyrighted Material and return as PDF file to jafes@asia.com or jafes.editor@gmail.com.
A written agreement shall be emailed to the requester should permission be granted.