Pituitary Hyperplasia and Van Wyk Grumbach Syndrome: A Consequence of Chronic Untreated Congenital Hypothyroidism

  • Deep Dutta Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Manoj Kumar Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Rajesh Jain Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Anubhav Thukral Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Sujoy Ghosh Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Satinath Mukhopadhyay Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India
  • Subhankar Chowdhury Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research & Seth Sukhlal Karani Memorial Hospital, Calcutta, India

Abstract

An eight-year, 4-month old Indian girl with low IQ and delayed milestones, presented with headache (4 years), breast development (4 months), and menstrual bleeding for 22 days. Examination revealed short stature [height: 91.5 cm; SD score: -5.59], coarse dry skin, umbilical hernia (arrow), delayed reflexes, Tanner’s stage-3 breasts,    absent pubic and axillary hair

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References

Van Wyk JJ, Grumbach MM. Syndrome of precocious menstruation and galactorrhoea in juvenile hypothyroidism: An example of hormonal overlap in pituitary feedback. Journal of Pediatrics 1960;57:416–435.

Ryan GL, Feng X, d’Alva CB et al. Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. Journal of Clinical Endocrinology and Metabolism. 2007; 92:2312–2317.

Kroeze WK, Sheffler DJ, Roth BL. G-protein-coupled receptors at a glance. Journal of Cell Science. 2003; 116:4867–4869.

Jawadi MH,Ballonoff LB, Stears JC, Katz FH. Primary hypothyroidism and pituitary enlargement. Radiological evidence of pituitary regression. Arch Intern Med. 1978; 138:1555-1557.

Published
2014-05-24
How to Cite
Dutta, D., Kumar, M., Jain, R., Thukral, A., Ghosh, S., Mukhopadhyay, S., & Chowdhury, S. (2014). Pituitary Hyperplasia and Van Wyk Grumbach Syndrome: A Consequence of Chronic Untreated Congenital Hypothyroidism. Journal of the ASEAN Federation of Endocrine Societies, 28(1), 88. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/58
Section
Images in Endocrinology