Pituitary Hyperplasia and Van Wyk Grumbach Syndrome: A Consequence of Chronic Untreated Congenital Hypothyroidism
Abstract
An eight-year, 4-month old Indian girl with low IQ and delayed milestones, presented with headache (4 years), breast development (4 months), and menstrual bleeding for 22 days. Examination revealed short stature [height: 91.5 cm; SD score: -5.59], coarse dry skin, umbilical hernia (arrow), delayed reflexes, Tanner’s stage-3 breasts, absent pubic and axillary hairDownloads
References
Van Wyk JJ, Grumbach MM. Syndrome of precocious menstruation and galactorrhoea in juvenile hypothyroidism: An example of hormonal overlap in pituitary feedback. Journal of Pediatrics 1960;57:416–435.
Ryan GL, Feng X, d’Alva CB et al. Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. Journal of Clinical Endocrinology and Metabolism. 2007; 92:2312–2317.
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Jawadi MH,Ballonoff LB, Stears JC, Katz FH. Primary hypothyroidism and pituitary enlargement. Radiological evidence of pituitary regression. Arch Intern Med. 1978; 138:1555-1557.
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