A Trial of Oral Glucocorticoids in the Resolution of Recurrent Granulomatous Hypophysitis

A Case Report

Authors

DOI:

https://doi.org/10.15605/jafes.034.02.13

Keywords:

granulomatous hypophysitis, autoimmune hypophysitis, glucocorticoids

Abstract

Granulomatous hypophysitis is an extremely rare condition, with no established definitive treatment. An elderly Asian woman was diagnosed to have recurrent granulomatous hypophysitis 5 years after transsphenoidal surgery. No other intervention was done post-operatively. Since another surgery was not advisable due to the high probability of recurrence, she was started on a trial of oral glucocorticoids. After 3 months of steroid therapy, complete resolution of symptoms and sellar mass were achieved.

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Author Biographies

Katrina Rodriguez-Asuncion, Makati Medical Center

Fellow, Section of Endocrinology, Diabetes and Metabolism

Department of Internal Medicine

Makati Medical Center

Thelma Crisostomo

Section of Endocrinology, Diabetes and Metabolism

Department of Internal Medicine

Makati Medical Center

References

Prete A, Salvatori R. Hypophysitis. 2018. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext [Internet]. South Dartmouth, MA:MDText.com, Inc., 2000-. https://www.ncbi.nlm.nih.gov/books/NBK519842/.

Park HJ, Park SH, Kim JH, Kim YH. Idiopathic Granulomatous Hypophysitis with Rapid Onset: A Case Report. Brain Tumor Res Treat. 2019 Apr;7(1):57-61.https://doi.org/10.14791/btrt.2019.7.e22.

Hunn BHM, Martin WG, Simpson S, Mclean CA. Idiopathic granulomatous hypophysitis: a systematic review of 82 cases in the literature. Pituitary. 2014;17(4):357-65. https://doi.org/10.1007/s11102-013-0510-4.

Elgamal ME, Mohamed RMH, Fiad T, Elgamal EA. Granulomatous hypophysitis: rare disease with challenging diagnosis. Clin Case Rep. 2017;5(7):1147-51. https://www.ncbi.nlm.nih.gov/pubmed/28680614. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494403. https://doi.org/ 10.1002/ccr3.1007.

Shi J, Zhang J, Wu Q, Chen G, Zhang H, Bo W. Granulomatous hypophysitis: two case reports and literature review. J Zhejiang Univ Sci B. 2009;10(7):552-8. https://www.ncbi.nlm.nih.gov/pubmed/19585674. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704974. https://doi.org/10.1631/jzus.B0820355.

Published

2019-11-26

How to Cite

Rodriguez-Asuncion, K., & Crisostomo, T. (2019). A Trial of Oral Glucocorticoids in the Resolution of Recurrent Granulomatous Hypophysitis: A Case Report. Journal of the ASEAN Federation of Endocrine Societies, 34(2), 210–214. https://doi.org/10.15605/jafes.034.02.13

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Section

Case Reports