Case Report of a Pituitary Metastasis from Lung Adenocarcinoma Masquerading as Pituitary Adenoma

Radhamani Rajakumar; Ijaz Hallaj Rahmatullah; Anilah Abdul Rahim

doi:10.15605/jafes.035.01.24

Authors

Radhamani Rajakumar Hospital Raja Permaisuri Bainun Ipoh
Ijaz Hallaj Rahmatullah Hospital Raja Permaisuri Bainun Ipoh, https://orcid.org/0000-0002-7338-9091
Anilah Abdul Rahim Hospital Raja Permaisuri Bainun Ipoh

DOI:

https://doi.org/10.15605/jafes.035.01.24

Keywords:

pituitary metastasis, diabetes inspidus, lung adenocarcinoma

Abstract

Metastasis to the pituitary gland is an unusual situation in clinical practice and is typically observed in those with underlying malignancy with breast and lung being the commonest primary site. However, we report a case of an apparently well 49-year-old female with metastatic lung adenocarcinoma who presented with visual disturbance and diabetes insipidus related to pituitary metastasis as an initial presentation.

Downloads

Download data is not yet available.

Author Biographies

Radhamani Rajakumar, Hospital Raja Permaisuri Bainun Ipoh

Endocrine Fellow

Ijaz Hallaj Rahmatullah, Hospital Raja Permaisuri Bainun Ipoh,

Consultant Endocrinologist

Anilah Abdul Rahim, Hospital Raja Permaisuri Bainun Ipoh

Consultant Endocrinologist

References

Heaney AP. Clinical review: Pituitary carcinoma: Difficult diagnosis and treatment. J Clin Endocrinol Metab. 2011;96(12):3649-60. https://www.ncbi.nlm.nih.gov/pubmed/21956419. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277423. https://doi.org/10.1210/jc.2011-2031.

Branch CL Jr, Laws ER Jr. Metastatic tumors of the sella turcica masquerading as primary pituitary tumors. J Clin Endocrinol Metab.1987;65(3):469-74. https://www.ncbi.nlm.nih.gov/pubmed/3624409. https://doi.org/10.1210/jcem-65-3-469.

Morita A, Meyer FB, Laws ER Jr. Symptomatic pituitary metastases. J Neurosurg. 1998;89(1):69–73. https://www.ncbi.nlm.nih.gov/pubmed/9647174. https://doi.org/10.3171/jns.1998.89.1.0069.

Kontogeorgos G. Classification and pathology of pituitary tumors. Endocrine.2005; 28(1):27-35. https://www.ncbi.nlm.nih.gov/pubmed/16311407. https://doi.org/10.1385/ENDO:28:1:027.

Freda PU, Post KD. Differential diagnosis of sellar masses. Endocrinol Metab Clin North Am. 1999;28(1):81-117,vi. https://www.ncbi.nlm.nih.gov/pubmed/10207686. https://doi.org/10.1016/s0889-8529(05)70058-x.

Spinelli GP, Lo Russo G, Miele E, et al. Breast cancer metastatic to the pituitary gland: A case report. World J Surg Oncol. 2012;10:137. https://www.ncbi.nlm.nih.gov/pubmed/22776141. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443051. https://doi.org/10.1186/1477-7819-10-13.

Teears RJ, Silverman EM. Clinicopathologic review of 88 cases of carcinoma metastatic to the pituitary gland. Cancer. 1975;36(1):216-20. https://www.ncbi.nlm.nih.gov/pubmed/1203849. https://doi.org/10.1002/1097-0142(197507)36:1<216::aid-cncr2820360123>3.0.co;2-e.

Reddy P, Kalemkerian GP. Unusual Presentations of Lung Cancer: Case 1. Diabetes insipidus as the initial manifestation of non-small lung cancer. J Clin Oncol. 2002;20(23):4597-4602. https://www.ncbi.nlm.nih.gov/pubmed/12454118. https://doi.org/10.1200/JCO.2002.20.23.4597.

Fassett DR, Couldwell WT. Metastases to the pituitary gland. Neurosurg Focus. 2004;16(4); E8. https://www.ncbi.nlm.nih.gov/pubmed/15191337.

Morita A, Meyer FB, Laws ER Jr. Symptomatic pituitary metastases. J Neurosurg. 1998;89(1):69-73. https://www.ncbi.nlm.nih.gov/pubmed/9647174. https://doi.org/10.3171/jns.1998.89.1.0069.