Relationship between Plasma Adiponectin Level and Corrected QT interval in Smoker and Non-Smoker Adult Male Subjects

Yin Thu Theint; Ei Ei Khin; Ohnmar Myint Thein; Mya Thanda Sein

doi:10.15605/jafes.035.02.09

Authors

Yin Thu Theint University of Medicine 2 https://orcid.org/0000-0002-3360-3436
Ei Ei Khin University of Medicine 2
Ohnmar Myint Thein University of Medicine 2 https://orcid.org/0000-0002-4947-0850
Mya Thanda Sein University of Medicine 2 https://orcid.org/0000-0002-5135-3418

DOI:

https://doi.org/10.15605/jafes.035.02.09

Keywords:

smoker, adiponectin, QTc

Abstract

Objective. This study determined the relationship between plasma adiponectin level and corrected QT interval (QTc) in smokers and non-smokers.

Methodology. This cross-sectional analytical study was undertaken in 30 smokers and 30 non-smokers. Plasma
adiponectin level was determined by enzyme-linked immunosorbent assay (ELISA). The QT interval was measured by routine 12-lead ECG with Lead II rhythm and QTc was calculated.

Results. Mean plasma adiponectin level was significantly lower in smokers (27.89±15 μg/ml) than that of non-smokers (52.13±21.57μg/ml) (p<0.001). Mean QTc interval was significantly longer in smokers than that of non-smokers (415.37±29.9 versus 395.63±26.13 ms, p<0.01). Higher risk of low adiponectin level (odds ratio [OR],8.1; 95% confidence interval [CI],1.61-40.77) and QTc interval prolongation (OR,6; 95%CI,1.17-30.73) were observed in smokers. There was weak significant negative correlation between plasma adiponectin level and QTc interval in the study population (n=60, r=-0.407, p=0.001). Moreover, low plasma adiponectin level was significantly associated with prolonged QTc interval in the study population (n=60, Fisher's exact p value<0.05). Risk of QTc interval prolongation was 4.3 times higher in subjects with low plasma adiponectin level (OR,4.27; 95% CI,1.05-17.46).

Conclusion. Smokers have greater risk for low plasma adiponectin level and prolonged QTc interval. There is a relationship between plasma adiponectin level and QTc interval.

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Author Biographies

Yin Thu Theint, University of Medicine 2

Assistant Lecturer, Department of Physiology

Yangon

Ei Ei Khin, University of Medicine 2

Associate Professor, Department of Physiology

Yangon

Ohnmar Myint Thein, University of Medicine 2

Professor, Department of Physiology

Yangon

Mya Thanda Sein, University of Medicine 2

Professor and Head, Department of Physiology

Yangon

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