Genetics of Obesity in Asia

Authors

  • Eva Maria Cutiongco-de la Paz Director Institute of Human Genetics, National Institutes of Health University of the Philippines, Manila

Abstract

The obesity epidemic is recognized globally as a significant public health concern. The World Health Organization estimates that approximately 2-3 billion people will be overweight and over 700 million will be obese by 2015.1 Earlier identified as a problem confined in developed countries, many developing countries have recently shown a significant rise of obesity cases.2 It is a major cause of disability and premature deaths in both developed and developing countries from obesity-related diseases such as cardiovascular disease, strokes and complications of diabetes.

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References

World Health Organization. Obesity and overweight. Fact Sheet No. 311, September 2006.

Ramachandran A and Snehalatha C. Rising burden of obesity in Asia. Journal of Obesity. 2010.

Nguyen D and Serag H. Epidemiology of obesity. Gastroenterol Clin North Am. 2010; 39(1): 1–7.

Yoon K-H, Lee J-H, Kim et al Epidemic obesity and type 2 diabetes in Asia. The Lancet 2006;368; (9548): 1681-1688.

Vimaleswaran K and Loos R. Progress in genetics of obesity. Expert Rev Mol Med. 2010; Feb 26;12e7

Motulsky A/ J Zhejiang Genetics of complex diseases.SCIENCE B 2006 7(2):167-168.

Farooqi IS and O’Rahilly S Genetic factors in human obesity. Obesity Reviews.2007;8 (Suppl 1) 37-40.

Stunkard AJ, Foch TT, Hrubec Z A twin study of human obesity. JAMA. 1986;256:51-54.

Daly AK and Day CP Candidate gene case-control association studies: Advantages and potential pitfalls. Br J Clin Pharmacol.2001; 52:489-499.

Shi J et al. Evaluation of genetic susceptibility loci for obesity in Chinese women. Am J Epidemiol. 2010;172:244–254.

Qi Q et al. Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population. Plos One. 2010;(5) Issue 5

Chang Y-C et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. Diabetes. 2008; (57):2245–2252

Tan J et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. Diabetes. 2008; 57:851–2857.:851–2857.

Hotta K et al. Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet. 2008; 53:546–553

Herbert A et al. A common genetic variant is associated with adult and childhood obesity. Science. 2006; 312:279–283.

Hotta K et al. INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet. 2008; 53:857–862.

Cha S et al. Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations. BMC Medical Genetics. 2009;10:96.

Marvelle A, Lange L, Qin L, Adair L, and Mohlke K. Association of FTO with Obesity-Related Traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. Diabetes.2008 ; 57: 1987-1991.

Schrauwen P and Hesselink M. UCP2 and UCP3 in muscle controlling body metabolism. The Journal of Experimental Biology. 2002; 205: 2275-2285.

Published

2014-05-28

How to Cite

Cutiongco-de la Paz, E. M. (2014). Genetics of Obesity in Asia. Journal of the ASEAN Federation of Endocrine Societies, 26(2), 168. Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/90

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Review Articles

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