Rate of Weight Gain and its Association with Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) among Obese Children attending Paediatric Endocrine Clinic, Hospital Universiti Sains Malaysia

Keywords: HOMA-IR, prognostic factor, obesity, insulin resistance


Objective. We aimed to study the median time to gain weight from baseline and  factors that were associated with rate of weight gain among obese children attending pediatric endocrine clinic Hospital USM.

Methodology. We recruited 70 participants with the mean age of 10.1 + 2.94 years with exogenous or simple form of obesity from June 2019 until September 2020. We analyzed their demography (age, gender, ethnicity, family background), measured their anthropometry (weight, height, BMI) and monitored monthly weight increment and finally analyzed their HOMA-IR at baseline and after 6 months of follow up.

Results. The mean time to gain 5 kg from baseline was 16 weeks (95% CI): (15.2, 16.7). Multivariate analysis showed only HOMA-IR after 6 months was a significant predictor affecting time to gain 5 kg; Adjusted HR: (95%CI) 1.617(1.232, 2.123), (p=0.001).

Conclusion. The time to gain 5 kg from baseline weight was increased 1.6 times in the presence of insulin resistance at 6 months follow up in patients with obesity. More intensive education and closed follow-up are recommended for children with obesity.


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Author Biographies

Siti Hasmiza Che Mat, Hospital Universiti Sains Malaysia

Department of Paediatrics

Najib Majdi Yaacob, Universiti Sains Malaysia

Medical Lecturer/ Public Health Specialist, Department of Biostatistics and Research Methodology, School of Medical Science,

Suhaimi Hussain, Hospital Universiti Sains Malaysia

Consultant Paediatric Endocrinologist, Department of Paediatrics


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How to Cite
Che Mat, S. H., Yaacob, N. M., & Hussain, S. (2021). Rate of Weight Gain and its Association with Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) among Obese Children attending Paediatric Endocrine Clinic, Hospital Universiti Sains Malaysia. Journal of the ASEAN Federation of Endocrine Societies, 36(2). Retrieved from https://asean-endocrinejournal.org/index.php/JAFES/article/view/1043
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