Metastatic Adenocarcinoma Arising from Fibrocalcific Pancreatic Diabetes
Abstract
Fibrocalcific pancreatic diabetes (FCPD) is a rare form of ketosis-resistant diabetes in the young (15 to 40 years old) of unknown etiology. It has been observed in tropical and subtropical countries with highest incidence in south India, and is believed to have some association with tropical chronic pancreatitis, malnutrition, toxin exposure (e.g., cassava) and SPINK1 mutation. It is associated with a hundredfold increased risk of pancreatic cancer compared to the general populationDownloads
References
Bhatia E, Choudhuri G, Sikora SS et al. Tropical calcific pancreatitis: Strong association with SPINK1 trypsin inhibitor mutation. Gastroenterology 2002;123(4):1020-5.
Braganza JM, Sherry J, Indira P et al. Xenobiotics and tropical chronic pancreatitis. Int J Pancreatology 1990:222–45.
Chari ST, Mohan V, Pitchumoni CS et al. Risk of pancreatic carcinoma in tropical calcific pancreatitis: An epidemiologic study. Pancreas 1994;9(1):62-6.
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